Title : Stress decreases serotonin tone in the nucleus accumbens in male mice to promote aversion and potentiate cocaine preference via decreased stimulation of 5-HT1B receptors.

Pub. Date : 2022 Mar

PMID : 34564712






3 Functional Relationships(s)
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1 Stress decreases serotonin tone in the nucleus accumbens in male mice to promote aversion and potentiate cocaine preference via decreased stimulation of 5-HT1B receptors. Serotonin 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus
2 5-HT1B is known to be expressed on 5-HT terminals in NAc, and 5-HT1B transcript was also detected in Pdyn+, Adora2a+ and ChAT+ (markers for direct pathway, indirect pathway, and cholinergic interneurons, respectively). Serotonin 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus
3 These findings suggest that Dyn/KOR regulates serotonin activation of 5HT1B receptors within the mNAc and dynamically controls stress response, affect, and drug reward. Serotonin 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus