Title : The Protective Effect of Natural Compounds on Doxorubicin-Induced Cardiotoxicity via Nicotinamide Adenine Dinucleotide Phosphate Oxidase Inhibition.

Pub. Date : 2022 Mar 3

PMID : 34562089






2 Functional Relationships(s)
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1 KEY FINDINGS: Oxidative stress and p53 play an important role in DOX-associated cardiotoxicity. Doxorubicin tumor protein p53 Homo sapiens
2 DOX activates nicotinamide adenine dinucleotide phosphate NADPH oxidase (NOX) in the heart, resulting in excessive reactive oxygen species that can induce cardiomyocyte apoptosis through phosphorylation of p53, DNA damage and/or mitogen-activated protein kinases-mediated cardiomyocyte apoptosis. Doxorubicin tumor protein p53 Homo sapiens