Pub. Date : 2021 Oct
PMID : 34553421
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PA treatment significantly induced the expressions of 5-HT2C R and ADAR2 in pancreatic MIN6 beta cells. | Palmitic Acid | 5-hydroxytryptamine (serotonin) receptor 2C | Mus musculus |
| 2 | PA treatment significantly induced the editing of 5-HT2C R in pancreatic MIN6 beta cells. | Palmitic Acid | 5-hydroxytryptamine (serotonin) receptor 2C | Mus musculus |
| 3 | Moreover, 5-HT2C R edited isoforms displayed reduced endoplasmic reticulum (ER) calcium release and store-operated calcium entry (SOCE) activation, probably through inhibition of stromal interaction molecule 1 trafficking under PA treatment. | Palmitic Acid | 5-hydroxytryptamine (serotonin) receptor 2C | Mus musculus |
| 4 | Altogether, our results show that PA-mediated editing of 5-HT2C R modulates GSIS through alteration of ER calcium release and SOCE activation in pancreatic MIN6 beta cells. | Palmitic Acid | 5-hydroxytryptamine (serotonin) receptor 2C | Mus musculus |