Pub. Date : 2021 Nov
PMID : 34551586
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Clinically Translatable Prevention of Anthracycline Cardiotoxicity by Dexrazoxane Is Mediated by Topoisomerase II Beta and Not Metal Chelation. | Dexrazoxane | DNA topoisomerase II beta | Homo sapiens |
| 2 | DEX, but not ADR-925, inhibited and depleted TOP2B and prevented daunorubicin-induced genotoxic damage. | Dexrazoxane | DNA topoisomerase II beta | Homo sapiens |
| 3 | TOP2B dependency of the cardioprotective effects was probed and supported by experiments with diastereomers of a new DEX derivative. | Dexrazoxane | DNA topoisomerase II beta | Homo sapiens |