Title : HIF-1α Hydroxyprolines Modulate Oxygen-Dependent Protein Stability Via Single VHL Interface With Comparable Effect on Ubiquitination Rate.

Pub. Date : 2021 Nov 5

PMID : 34537235






1 Functional Relationships(s)
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1 The principal step in this critical cellular process is the hydroxylation of either or both of the two conserved proline residues P402 and P564 within the oxygen-dependent degradation domain (ODD) of HIF-1alpha subunit via prolyl hydroxylases, which is necessary for binding VHL. Proline von Hippel-Lindau tumor suppressor Homo sapiens