Title : Innovative therapies for neuroblastoma: The surprisingly potent role of iron chelation in up-regulating metastasis and tumor suppressors and down-regulating the key oncogene, N-myc.

Pub. Date : 2021 Nov

PMID : 34536548






2 Functional Relationships(s)
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1 The classical iron-binding ligand, desferrioxamine (DFO), has demonstrated effective anti-proliferative activity against many cancer-types, particularly neuroblastoma tumors, and has the surprising activity of down-regulating the potent oncogene, N-myc, which is a major oncogenic driver in neuroblastoma. Deferoxamine v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived Mus musculus
2 The classical iron-binding ligand, desferrioxamine (DFO), has demonstrated effective anti-proliferative activity against many cancer-types, particularly neuroblastoma tumors, and has the surprising activity of down-regulating the potent oncogene, N-myc, which is a major oncogenic driver in neuroblastoma. Deferoxamine v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived Mus musculus