Title : Reversing Multidrug Resistance by Inducing Mitochondrial Dysfunction for Enhanced Chemo-Photodynamic Therapy in Tumor.

Pub. Date : 2021 Sep 29

PMID : 34533937






1 Functional Relationships(s)
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1 Intriguingly, the PDT-induced in situ mitochondrial dysfunction led to intracellular ATP reduction, which triggered the downregulated P-glycoprotein transportation capacity and thus resulted in diminishing the efflux of chemotherapeutic agents and increasing drug uptake by drug-resistant cells. Adenosine Triphosphate ATP binding cassette subfamily B member 1 Homo sapiens