Pub. Date : 2021
PMID : 34531748
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Here, we show that activation of AMPK by AICAR, a direct AMPK agonist, significantly ameliorates sodium taurocholate-induced PALI in rats, whereas treatment of PALI rats with the AMPK antagonist Compound C profoundly exacerbates the degree of liver injury, suggesting that hepatic AMPK activation exerts an essential protective role in PALI. | Taurocholic Acid | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |
2 | Mechanistically, AICAR induces AMPK activation, which in turn activates nuclear factor erythroid 2-related factor 2(Nrf2) -regulated hepatic antioxidant capacity and inhibits NLRP3 inflammasome-mediated pyrolysis, protecting rats from sodium taurocholate-induced PALI. | Taurocholic Acid | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |