Pub. Date : 2021 Nov
PMID : 34531295
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tacrine induces endoplasmic reticulum-stressed apoptosis via disrupting the proper assembly of oligomeric acetylcholinesterase in cultured neuronal cells. | Tacrine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | Here, we found tacrine could disrupt the proper trafficking of proline-rich membrane anchor-linked tetrameric AChE in the endoplasmic reticulum (ER). | Tacrine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | The exposure of tacrine in cells expressing AChE, e.g. neuron, caused an accumulation of the misfolded AChE in the ER. | Tacrine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | The exposure of tacrine in cells expressing AChE, e.g. neuron, caused an accumulation of the misfolded AChE in the ER. | Tacrine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 5 | The ER stress and apoptosis, induced by tacrine, were proportional to the amount of AChE. | Tacrine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 6 | Our study reports tacrine and other AChEIs disrupt the proper trafficking of AChE in the endoplasmic reticulum. | Tacrine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |