Pub. Date : 2021 Sep 16
PMID : 34528900
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin-induced chemosensitization to cisplatin depends on P53 status and is inhibited by Jarid1b overexpression in non-small cell lung cancer cells. | Metformin | tumor protein p53 | Homo sapiens |
| 2 | Here we test if the presence of P53 could predict the activity of metformin as an adjuvant for cisplatin-based therapy in non-small cell lung cancer (NSCLC). | Metformin | tumor protein p53 | Homo sapiens |
| 3 | Metformin sensitized A549 and HCC 827 cells (but not H1299 and H358 cells) to cisplatin in a P53-dependent manner, changing its subcellular localization to the mitochondria. | Metformin | tumor protein p53 | Homo sapiens |
| 4 | Treatment with a sub-lethal dose of cisplatin increased Jarid1b expression, yet downregulated P53 levels, protecting A549Res cells from metformin-induced chemosensitization to cisplatin and favored a glycolytic phenotype. | Metformin | tumor protein p53 | Homo sapiens |
| 5 | In conclusion, metformin could potentially be used as an adjuvant for cisplatin-based therapy in NSCLC cells if wild type P53 is present. | Metformin | tumor protein p53 | Homo sapiens |