Title : Lipid-dependent sequential allosteric activation of heat-sensing TRPV1 channels by anchor-stereoselective "hot" vanilloid compounds and analogs.

Pub. Date : 2021 Dec

PMID : 34504955






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Both a silent resident phosphatidylinositol lipid and a "hot" vanilloid agonist capsaicin or resiniferatoxin have been shown to share the same inter-subunit binding pocket between a voltage sensor like domain and a pore domain in TRPV1. resiniferatoxin transient receptor potential cation channel subfamily V member 1 Homo sapiens