Title : A strategy to assess the cellular activity of E3 ligase components against neo-substrates using electrophilic probes.

Pub. Date : 2022 Jan 20

PMID : 34499862






1 Functional Relationships(s)
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1 We demonstrate that electroporated recombinant von Hippel-Lindau (VHL) protein, covalently functionalized at its ligandable cysteine with JQ1 or dasatinib, induces degradation of BRD4 or tyrosine kinases, respectively. Cysteine bromodomain containing 4 Homo sapiens