Title : Physiologically-Based Pharmacokinetic Modelling of Entrectinib Parent and Active Metabolite to Support Regulatory Decision-Making.

Pub. Date : 2021 Nov

PMID : 34495458






1 Functional Relationships(s)
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1 Co-administration of moderate CYP3A4 inducers (efavirenz, carbamazepine, phenytoin) was predicted to result in an average decrease in entrectinib exposure between 45 and 79%, with corresponding average decreases for M5 of approximately 50%. efavirenz cytochrome P450 family 3 subfamily A member 4 Homo sapiens