Pub. Date : 2021 Oct
PMID : 34492522
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Colchicine reduces extracellular vesicle NLRP3 inflammasome protein levels in chronic coronary disease: A LoDoCo2 biomarker substudy. | Colchicine | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Colchicine has broad anti-inflammatory effects and part of the atheroprotective effects have been suggested to be the result of NLRP3 inflammasome inhibition. | Colchicine | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | EV NLRP3 protein levels were lower in patients treated with colchicine (median 1.38 ng/mL), compared to placebo (median 1.58 ng/mL) (p = 0.025). | Colchicine | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | CONCLUSIONS: Colchicine leads to a reduction of EV NLRP3 protein levels. | Colchicine | NLR family pyrin domain containing 3 | Homo sapiens |
| 5 | This indicates that inhibitory effects on the NLRP3 inflammasome might contribute to the atheroprotective effects of colchicine in coronary disease. | Colchicine | NLR family pyrin domain containing 3 | Homo sapiens |