Pub. Date : 2021
PMID : 34490270
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | alpha1-nAchR-Mediated Signaling Through Lipid Raft Is Required for Nicotine-Induced NLRP3 Inflammasome Activation and Nicotine-Accelerated Atherosclerosis. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 2 | alpha1-nAchR-Mediated Signaling Through Lipid Raft Is Required for Nicotine-Induced NLRP3 Inflammasome Activation and Nicotine-Accelerated Atherosclerosis. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 3 | Mechanically, nicotine increased the expression of alpha1-nAChR and stimulated the accumulation of alpha1-nAChR in lipid raft, leading to NLRP3 inflammasome activation in macrophage. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 4 | Conversely, silencing of alpha1-nAChR in macrophage sufficiently blocked the pro-inflammasome activation effect of nicotine, indicating that alpha1-nAChR was the specific receptor for nicotine in triggering NLRP3 inflammasome in macrophage. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 5 | Conversely, silencing of alpha1-nAChR in macrophage sufficiently blocked the pro-inflammasome activation effect of nicotine, indicating that alpha1-nAChR was the specific receptor for nicotine in triggering NLRP3 inflammasome in macrophage. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 6 | Furthermore, both the destruction of lipid raft by methyl-beta-cyclodextrin and the interference of lipid raft clustering by silencing acid sphingomyelinase reversed nicotine-induced NLRP3 inflammasome activation by reducing the accumulation of alpha1-nAChR in lipid raft in macrophage, suggesting lipid raft-mediated accumulation of alpha1-nAChR was the key event in regulating the pro-inflammatory effects of nicotine in macrophage. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 7 | Furthermore, both the destruction of lipid raft by methyl-beta-cyclodextrin and the interference of lipid raft clustering by silencing acid sphingomyelinase reversed nicotine-induced NLRP3 inflammasome activation by reducing the accumulation of alpha1-nAChR in lipid raft in macrophage, suggesting lipid raft-mediated accumulation of alpha1-nAChR was the key event in regulating the pro-inflammatory effects of nicotine in macrophage. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 8 | Conclusion: alpha1-nAChR-mediated signaling through lipid raft is required for NLRP3 inflammasome activation and pro-atherosclerotic property of nicotine. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |