Title : [Role of NF-κB p65 and related cytokines in rats with liver function injury induced by dibutyl phthalate and benzo (a) pyrene].

Pub. Date : 2021 Aug 20

PMID : 34488261






7 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 While the level of TNF-alpha in each exposure group was higher than those in the blank control group and the levels of TNF-alpha in the DBP and BaP co-exposed groups were strongly augmented compared to those in the low and high dose groups that single-exposed to DBP and BaP (P<0.05) . Benzo(a)pyrene tumor necrosis factor Rattus norvegicus
2 While the level of TNF-alpha in each exposure group was higher than those in the blank control group and the levels of TNF-alpha in the DBP and BaP co-exposed groups were strongly augmented compared to those in the low and high dose groups that single-exposed to DBP and BaP (P<0.05) . Benzo(a)pyrene tumor necrosis factor Rattus norvegicus
3 While the level of TNF-alpha in each exposure group was higher than those in the blank control group and the levels of TNF-alpha in the DBP and BaP co-exposed groups were strongly augmented compared to those in the low and high dose groups that single-exposed to DBP and BaP (P<0.05) . Benzo(a)pyrene tumor necrosis factor Rattus norvegicus
4 While the level of TNF-alpha in each exposure group was higher than those in the blank control group and the levels of TNF-alpha in the DBP and BaP co-exposed groups were strongly augmented compared to those in the low and high dose groups that single-exposed to DBP and BaP (P<0.05) . Benzo(a)pyrene tumor necrosis factor Rattus norvegicus
5 After BaP exposed alone, the NF-kappaB p65 protein expression level was positively correlated with TNF-alpha and ALT (r=0.911 and 0.910, P<0.05) . Benzo(a)pyrene tumor necrosis factor Rattus norvegicus
6 When DBP and BaP exposed together, NF-kappaB p65 protein expression level was positively correlated with CXCL-13, IL-6, TNF-alpha, ALT and AST (r=0.711, 0.764, 0.955, 0.903 and 0.827, P<0.05) . Benzo(a)pyrene tumor necrosis factor Rattus norvegicus
7 In addition, Pearson correlation analysis showed a positive correlation between TNF-alpha and ALT (r=0.833 and 0.894, P<0.05) when DBP or BaP exposed alone. Benzo(a)pyrene tumor necrosis factor Rattus norvegicus