Title : HIF2α regulates the synthesis and release of epinephrine in the adrenal medulla.

Pub. Date : 2021 Nov

PMID : 34480587






2 Functional Relationships(s)
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1 Here, we reveal that deficiency of HIF (hypoxia inducible factors) prolyl hydroxylase domain protein-2 (PHD2) in the adrenal medulla of mice results in HIF2alpha-mediated reduction in phenylethanolamine N-methyltransferase (PNMT) expression, and consequent reduction in epinephrine synthesis. Epinephrine phenylethanolamine-N-methyltransferase Mus musculus
2 Here, we reveal that deficiency of HIF (hypoxia inducible factors) prolyl hydroxylase domain protein-2 (PHD2) in the adrenal medulla of mice results in HIF2alpha-mediated reduction in phenylethanolamine N-methyltransferase (PNMT) expression, and consequent reduction in epinephrine synthesis. Epinephrine phenylethanolamine-N-methyltransferase Mus musculus