Pub. Date : 2021 Oct 26
PMID : 34478517
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | These manifestations depend on the BH3-profile of parental cells which guide the enhanced formation of Bcl-2:BIM and/or dynamic (i.e. treatment-induced) formation of Bcl-xL:BIM and Bcl-xL:BAK complexes. | BH 3 | BCL2 like 1 | Homo sapiens |
| 2 | These manifestations depend on the BH3-profile of parental cells which guide the enhanced formation of Bcl-2:BIM and/or dynamic (i.e. treatment-induced) formation of Bcl-xL:BIM and Bcl-xL:BAK complexes. | BH 3 | BCL2 like 1 | Homo sapiens |
| 3 | Accordingly, an unbiased high-throughput drug (n=528) screening approach highlighted alternative BH3 mimetics as top combination partners for MCL-1 inhibitors in sensitive and resistant cells (Bcl-xL>Bcl-2 inhibition), whereas established drug classes were mainly antagonistic (e.g. anti-mitotic agents). | BH 3 | BCL2 like 1 | Homo sapiens |