Title : Coordinated regulation of endothelial calcium signaling and shear stress-induced nitric oxide production by PKCβ and PKCη.

Pub. Date : 2021 Nov

PMID : 34474112






2 Functional Relationships(s)
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1 OBJECTIVE: We hypothesized that PKCbeta and PKCeta differentially modulate shear stress-induced nitric oxide (NO) production by regulating the transduced calcium signals and the resultant eNOS activation. Calcium nitric oxide synthase 3 Bos taurus
2 RESULTS: PKCeta proved to be a robust regulator of agonist- and shear stress-induced eNOS activation, modulating calcium fluxes and tuning eNOS activity by multi-site phosphorylation. Calcium nitric oxide synthase 3 Bos taurus