Title : l-lactic acidosis confers insensitivity to PKC inhibitors by competing forĀ uptake via monocarboxylate transporters.

Pub. Date : 2022 Jan

PMID : 34472101






1 Functional Relationships(s)
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1 Interestingly, blockade of lactate transporters, monocarboxylate transporter-1 and -4 (MCT1 and MCT4), attenuated the intracellular level of GO6983, and its inhibitory effect on PKC activity, suggesting that lactic acid promotes the resistance to PKC inhibitors by competing for the uptake through these transporters rather than by activating its receptor, GPR81. Lactic Acid hydroxycarboxylic acid receptor 1 Homo sapiens