Pub. Date : 2021
PMID : 34457117
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Salidroside Suppresses the Proliferation and Migration of Human Lung Cancer Cells through AMPK-Dependent NLRP3 Inflammasome Regulation. | rhodioloside | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | It has been shown that SAL improves metabolic inflammation in diabetic rodents through AMP-activated protein kinase- (AMPK-) dependent inhibition of the NLRP3 inflammasome. | rhodioloside | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | However, whether the NLRP3 inflammasome is regulated by SAL in NSCLC cells and how its underlying mechanism(s) can be determined require clarification. | rhodioloside | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | Moreover, SAL protected A549 cells against LPS-induced AMPK inhibition, ROS production, and NLRP3 inflammasome activation. | rhodioloside | NLR family pyrin domain containing 3 | Homo sapiens |
| 5 | In summary, these results indicate that SAL suppresses the proliferation and migration of human lung cancer cells through AMPK-dependent NLRP3 inflammasome regulation. | rhodioloside | NLR family pyrin domain containing 3 | Homo sapiens |