Pub. Date : 2021 Aug 28
PMID : 34454514
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Virion assembly and maturation are facilitated by the cellular polyanion inositol hexaphosphate (IP6), which is proposed to stabilize both the immature Gag lattice and the mature capsid lattice by binding to rings of primary amines at the center of Gag or capsid protein (CA) hexamers. | Phytic Acid | Pr55(Gag) | Human immunodeficiency virus 1 |
| 2 | Virion assembly and maturation are facilitated by the cellular polyanion inositol hexaphosphate (IP6), which is proposed to stabilize both the immature Gag lattice and the mature capsid lattice by binding to rings of primary amines at the center of Gag or capsid protein (CA) hexamers. | Phytic Acid | Pr55(Gag) | Human immunodeficiency virus 1 |
| 3 | RESULTS: We found a mutation, a threonine to isoleucine substitution at position 371 (T371I) in Gag, that restored replication competence to an IP6-binding-deficient HIV-1 mutant. | Phytic Acid | Pr55(Gag) | Human immunodeficiency virus 1 |
| 4 | CONCLUSIONS: Overall these results suggest that IP6-Gag and Gag-Gag contacts are finely tuned to generate a Gag lattice of optimal stability, and that under certain conditions BVM can rescue IP6 deficiency. | Phytic Acid | Pr55(Gag) | Human immunodeficiency virus 1 |
| 5 | CONCLUSIONS: Overall these results suggest that IP6-Gag and Gag-Gag contacts are finely tuned to generate a Gag lattice of optimal stability, and that under certain conditions BVM can rescue IP6 deficiency. | Phytic Acid | Pr55(Gag) | Human immunodeficiency virus 1 |