Pub. Date : 2021 Oct 7
PMID : 34453839
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | KEY FINDINGS: Our data revealed that pretreatment with nebivolol and nebivolol/valsartan combination significantly reduced ANG II-induced oxidative stress and mTORC1 signalling. | Valsartan | angiotensinogen | Homo sapiens |
| 2 | Concurrently, ANG II-induced activation of inflammatory cytokines and fetal gene expressions were significantly suppressed by nebivolol and nebivolol/valsartan combination. | Valsartan | angiotensinogen | Homo sapiens |
| 3 | Pretreatment with nebivolol and nebivolol/valsartan combination alleviated ANG II-induced impairment of mitochondrial biogenesis by restoring the gene expression levels of PGC-1alpha, TFAM, NRF-1 and SIRT3. | Valsartan | angiotensinogen | Homo sapiens |
| 4 | SUMMARY: These findings suggest that both nebivolol and nebivolol/valsartan combination exert protective effects on ANG II-induced mitochondrial dysfunction by alleviating its biogenesis and dynamics. | Valsartan | angiotensinogen | Homo sapiens |