Title : Assessing the Functional Redundancy between P-gp and BCRP in Controlling the Brain Distribution and Biliary Excretion of Dual Substrates with PET Imaging in Mice.

Pub. Date : 2021 Aug 18

PMID : 34452247






1 Functional Relationships(s)
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1 We used positron emission tomography (PET) with the metabolically stable P-gp/BCRP substrates (11C)tariquidar, (11C)erlotinib, and (11C)elacridar to assess whether a similar functional redundancy as at the BBB exists in the liver, where both transporters mediate the biliary excretion of drugs. tariquidar ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus