Title : Stability of Methylphenidate under Various pH Conditions in the Presence or Absence of Gut Microbiota.

Pub. Date : 2021 Jul 27

PMID : 34451830






1 Functional Relationships(s)
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1 In silico analysis identified several small intestinal bacteria to harbor homologues of the human carboxylesterase 1 enzyme responsible for the hydrolysis of methylphenidate in the liver into the inactive form, ritalinic acid. ritalinic acid carboxylesterase 1 Homo sapiens