Pub. Date : 2021 Oct 15
PMID : 34437989
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PMA treatment fosters rat retinal ganglion cell survival via TNF signaling. | Tetradecanoylphorbol Acetate | tumor necrosis factor | Rattus norvegicus |
| 2 | We hypothesize that the increase in RGCs survival mediated by PMA treatment depends upon modulation of the levels of IL-1beta and TNF-alpha. | Tetradecanoylphorbol Acetate | tumor necrosis factor | Rattus norvegicus |
| 3 | The effect of PMA treatment was assayed on cell viability, caspase 3 activation, TNF-alpha and IL-1beta release and TNF receptor type I (TNFRI) and TNF receptor type II (TNFRII) levels. | Tetradecanoylphorbol Acetate | tumor necrosis factor | Rattus norvegicus |
| 4 | PMA treatment increases IL-1beta and TNF-alpha levels in 15 minutes in culture and increases the release of both cytokines after 30 minutes and 24h, respectively. | Tetradecanoylphorbol Acetate | tumor necrosis factor | Rattus norvegicus |
| 5 | Both IL-1beta and TNF-alpha levels decrease after 48h of PMA treatment. | Tetradecanoylphorbol Acetate | tumor necrosis factor | Rattus norvegicus |
| 6 | These data suggest that PMA treatment induces IL1beta and TNF-alpha release and modulation of TNFRI/TNFRII expression promoting RGCs survival after axotomy. | Tetradecanoylphorbol Acetate | tumor necrosis factor | Rattus norvegicus |