Pub. Date : 2021 Oct 1
PMID : 34432536
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | N-3-oxododecanoyl homoserine lactone exacerbates endothelial cell death by inducing receptor-interacting protein kinase 1-dependent apoptosis. | N-(3-oxododecanoyl)homoserine lactone | receptor interacting serine/threonine kinase 1 | Homo sapiens |
| 2 | In addition, we found that treatment with necrostatin-1, an RIPK1 inhibitor, reduced cell death and ameliorated the activation of the RIPK1-dependent apoptotic pathway in 3OC12-HSL-treated cells. | N-(3-oxododecanoyl)homoserine lactone | receptor interacting serine/threonine kinase 1 | Homo sapiens |
| 3 | In conclusion, 3OC12-HSL induced endothelial cell apoptosis via the activation of the RIPK1 pathway, independent of LPS toxicity. | N-(3-oxododecanoyl)homoserine lactone | receptor interacting serine/threonine kinase 1 | Homo sapiens |