Title : Combination of cafeteria diet with intraperitoneally streptozotocin in rats. A type-2 diabetes model.

Pub. Date : 2021

PMID : 34431921






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1 RESULTS: Lower weight gain, higher water intake, higher Lee index, hyperglycemia and modified total protein, urea, alpha-amylase, as well as insulin resistance, hepatic steatosis, pancreas, and kidney injury were observed in animals treated with 35 and 40 mg/kg of STZ. Streptozocin insulin Homo sapiens
2 CONCLUSIONS: The results show that the experimental model using cafeteria diet associated with 35 mg/kg of STZ is a low-cost model and efficient in order to develop DM2, confirmed by the presence of polydipsia, hyperglycemia, altered biochemical tests, insulin resistance and damages to the liver, pancreas and kidney, which is similar to the disease found in humans. Streptozocin insulin Homo sapiens