Pub. Date : 2022 Feb
PMID : 34427852
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glycyrrhizic Acid Alleviates Lipopolysaccharide (LPS)-Induced Acute Lung Injury by Regulating Angiotensin-Converting Enzyme-2 (ACE2) and Caveolin-1 Signaling Pathway. | Glycyrrhizic Acid | angiotensin converting enzyme 2 | Homo sapiens |
| 2 | Glycyrrhizic Acid Alleviates Lipopolysaccharide (LPS)-Induced Acute Lung Injury by Regulating Angiotensin-Converting Enzyme-2 (ACE2) and Caveolin-1 Signaling Pathway. | Glycyrrhizic Acid | angiotensin converting enzyme 2 | Homo sapiens |
| 3 | Our results showed that GA significantly attenuated LPS-induced ALI and decreased the production of inflammatory factors, including IL-1beta, MCP-1, COX2, HMGB1, and adhesion molecules, such as E-selectin, VCAM-1, and modulated expression of angiotensin-converting enzyme 2 (ACE2). | Glycyrrhizic Acid | angiotensin converting enzyme 2 | Homo sapiens |
| 4 | Our results showed that GA significantly attenuated LPS-induced ALI and decreased the production of inflammatory factors, including IL-1beta, MCP-1, COX2, HMGB1, and adhesion molecules, such as E-selectin, VCAM-1, and modulated expression of angiotensin-converting enzyme 2 (ACE2). | Glycyrrhizic Acid | angiotensin converting enzyme 2 | Homo sapiens |
| 5 | Moreover, treatment of ACE2 inhibitor (MLN-4760) reversed the effects of GA on the secretion of pro-inflammatory factors in ALI. | Glycyrrhizic Acid | angiotensin converting enzyme 2 | Homo sapiens |
| 6 | Additionally, GA exerts its protective effect by regulating the ACE2 and caveolin-1/NF-kappaB signaling pathway. | Glycyrrhizic Acid | angiotensin converting enzyme 2 | Homo sapiens |
| 7 | In conclusion, this study showed that GA alleviated LPS-induced ALI by upregulating ACE2 and inhibiting the caveolin-1/NF-kappaB signaling pathway. | Glycyrrhizic Acid | angiotensin converting enzyme 2 | Homo sapiens |