Title : CG223, a novel BET inhibitor, exerts TGF-β1-mediated antifibrotic effects in a murine model of bleomycin-induced pulmonary fibrosis.

Pub. Date : 2021 Oct

PMID : 34425215






1 Functional Relationships(s)
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1 Additionally, pulmonary fibroblasts isolated from bleomycin-instilled mice showed a significantly increased association of BRD4 with the promoters of two pro-fibrotic genes linked to the entry into the TGF-beta1 autocrine/paracrine loop, thrombospondin 1 (Thbs1) and integrin beta3 (Itgb3), as well as with the promoter of a myofibroblast marker gene, actin alpha 2 (Acta2). Bleomycin actin alpha 2, smooth muscle, aorta Mus musculus