Title : 6β-Hydroxytestosterone Promotes Angiotensin II-Induced Hypertension via Enhanced Cytosolic Phospholipase A2α Activity.

Pub. Date : 2021 Sep

PMID : 34420370






2 Functional Relationships(s)
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1 This study was conducted to test the hypothesis that the CYP1B1 (cytochrome P450 1B1)-testosterone metabolite 6beta-hydroxytestosterone contributes to angiotensin II-induced hypertension by promoting activation of group IV cPLA2alpha (cytosolic phospholipase A2alpha) and generation of prohypertensive eicosanoids in male mice. 6 beta-hydroxytestosterone cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus
2 This study was conducted to test the hypothesis that the CYP1B1 (cytochrome P450 1B1)-testosterone metabolite 6beta-hydroxytestosterone contributes to angiotensin II-induced hypertension by promoting activation of group IV cPLA2alpha (cytosolic phospholipase A2alpha) and generation of prohypertensive eicosanoids in male mice. 6 beta-hydroxytestosterone cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus