Title : Inhibition of sEH via stabilizing the level of EETs alleviated Alzheimer's disease through GSK3β signaling pathway.

Pub. Date : 2021 Oct

PMID : 34411643






1 Functional Relationships(s)
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1 Furthermore, inhibition of sEH could ameliorate neuroinflammation, neuronal death, and oxidative stress via stabilizing the in vivo level of epoxyeicosatrienoic acids (EETs), especially 8,9-EET and 14,15-EET, further resulting in the anti-AD effect through the regulation of GSK3beta-mediated NF-kappaB, p53, and Nrf2 signaling pathways. 14,15-epoxy-5,8,11-eicosatrienoic acid epoxide hydrolase 2, cytoplasmic Mus musculus