Pub. Date : 2021 Oct 19
PMID : 34411575
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PIP2-induced membrane binding of the Vinculin tail competes with its other binding partners. | Phosphatidylinositol 4,5-Diphosphate | vinculin | Homo sapiens |
| 2 | Vinculin plays a key role during the first phase of focal adhesion formation and interacts with the plasma membrane through specific binding of its Tail domain to the lipid phosphatidylinositol 4,5-bisphosphate (PIP2). | Phosphatidylinositol 4,5-Diphosphate | vinculin | Homo sapiens |
| 3 | Vinculin plays a key role during the first phase of focal adhesion formation and interacts with the plasma membrane through specific binding of its Tail domain to the lipid phosphatidylinositol 4,5-bisphosphate (PIP2). | Phosphatidylinositol 4,5-Diphosphate | vinculin | Homo sapiens |
| 4 | This allowed us to map the interaction of the Vinculin Tail with PIP2-enriched membranes at atomistic detail. | Phosphatidylinositol 4,5-Diphosphate | vinculin | Homo sapiens |
| 5 | Importantly, many of these PIP2 binding residues are also involved in maintaining Vinculin in a closed, auto-inhibited conformation. | Phosphatidylinositol 4,5-Diphosphate | vinculin | Homo sapiens |