Title : Design, Synthesis and Biological Evaluation of New N-Acyl Hydrazones with a Methyl Sulfonyl Moiety as Selective COX-2 Inhibitors.

Pub. Date : 2021 Nov

PMID : 34411436






1 Functional Relationships(s)
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1 A methyl sulfonyl pharmacophore was added to the structure in order to increase the affinity for the polar side pocket present in the COX-2 enzyme. methyl sulfonyl mitochondrially encoded cytochrome c oxidase II Homo sapiens