Title : Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats.

Pub. Date : 2021 Jul

PMID : 34386323






1 Functional Relationships(s)
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1 CP-25 and GRK2 inhibitors (paroxetine or GSK180736A) inhibited the abnormal proliferation of FLS in RA patients and CIA rats by down-regulating GRK2 translocation to EP4 receptor. Paroxetine G protein-coupled receptor kinase 2 Rattus norvegicus