Title : Anthelminthic niclosamide inhibits tumor growth and invasion in cisplatin-resistant human epidermal growth factor receptor 2-positive breast cancer.

Pub. Date : 2021 Sep

PMID : 34386088






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1 Anthelminthic niclosamide inhibits tumor growth and invasion in cisplatin-resistant human epidermal growth factor receptor 2-positive breast cancer. Niclosamide erb-b2 receptor tyrosine kinase 2 Homo sapiens
2 However, the specific function and underlying mechanism of action of niclosamide in chemoresistant human epidermal growth factor receptor 2 (HER2)-positive breast cancer remain unknown. Niclosamide erb-b2 receptor tyrosine kinase 2 Homo sapiens
3 The present study aimed to determine whether niclosamide can inhibit cell proliferation, invasion and epithelial-to-mesenchymal transition, as well as the stem-like phenotype in cisplatin-resistant HER2-positive breast cancer. Niclosamide erb-b2 receptor tyrosine kinase 2 Homo sapiens
4 The results from the present study demonstrated that niclosamide inhibited the resistance of HER2-positive breast cancer to cisplatin both in vitro and in vivo. Niclosamide erb-b2 receptor tyrosine kinase 2 Homo sapiens
5 Taken together, the results of the present study suggested that niclosamide combined with cisplatin may be considered as a novel treatment for chemoresistant HER2-positive breast cancer. Niclosamide erb-b2 receptor tyrosine kinase 2 Homo sapiens