Pub. Date : 2021 Aug 17
PMID : 34385322
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Structures of ABCB4 provide insight into phosphatidylcholine translocation. | Phosphatidylcholines | ATP binding cassette subfamily B member 4 | Homo sapiens |
| 2 | ABCB4 is expressed in hepatocytes and translocates phosphatidylcholine into bile canaliculi. | Phosphatidylcholines | ATP binding cassette subfamily B member 4 | Homo sapiens |
| 3 | Its choline moiety is stabilized by cation-pi interactions with an essential tryptophan residue, rationalizing the specificity of ABCB4 for phosphatidylcholine. | Phosphatidylcholines | ATP binding cassette subfamily B member 4 | Homo sapiens |
| 4 | Using a proteoliposome-based translocation assay with fluorescently labeled phosphatidylcholine analogs, we recapitulated the substrate specificity of ABCB4 in vitro and confirmed the role of the key tryptophan residue. | Phosphatidylcholines | ATP binding cassette subfamily B member 4 | Homo sapiens |