Title : Structures of ABCB4 provide insight into phosphatidylcholine translocation.

Pub. Date : 2021 Aug 17

PMID : 34385322






2 Functional Relationships(s)
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1 Its choline moiety is stabilized by cation-pi interactions with an essential tryptophan residue, rationalizing the specificity of ABCB4 for phosphatidylcholine. Tryptophan ATP binding cassette subfamily B member 4 Homo sapiens
2 Using a proteoliposome-based translocation assay with fluorescently labeled phosphatidylcholine analogs, we recapitulated the substrate specificity of ABCB4 in vitro and confirmed the role of the key tryptophan residue. Tryptophan ATP binding cassette subfamily B member 4 Homo sapiens