Pub. Date : 2021 Nov
PMID : 34382905
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AMPK-activated ULK1 phosphorylates PIKFYVE to drive formation of PtdIns5P-containing autophagosomes during glucose starvation. | phosphatidylinositol 5-phosphate | unc-51 like autophagy activating kinase 1 | Homo sapiens |
| 2 | Recently, we described a non-canonical signaling pathway involving the kinases AMPK, ULK1 and PIKFYVE that are induced during glucose starvation, leading to the formation of PtdIns5P-containing autophagosomes, resulting in increased autophagy flux and clearance of autophagy substrates. | phosphatidylinositol 5-phosphate | unc-51 like autophagy activating kinase 1 | Homo sapiens |
| 3 | ULK1 then phosphorylates PIKFYVE at S1548, leading to its activation and increased PtdIns5P formation, which enables the recruitment of machinery required for autophagosome biogenesis. | phosphatidylinositol 5-phosphate | unc-51 like autophagy activating kinase 1 | Homo sapiens |