Pub. Date : 2021 Sep
PMID : 34373022
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Association of EPHX1 polymorphisms with plasma concentration of carbamazepine in epileptic patients: Systematic review and meta-analysis. | Carbamazepine | epoxide hydrolase 1 | Homo sapiens |
| 2 | Increasing evidence suggested that polymorphisms in Epoxide Hydrolase1 (EPHX1) gene are associated with the pharmacokinetics (PK) and pharmacodynamics (PD) of CBZ, albeit the results were inconsistent. | Carbamazepine | epoxide hydrolase 1 | Homo sapiens |
| 3 | Increasing evidence suggested that polymorphisms in Epoxide Hydrolase1 (EPHX1) gene are associated with the pharmacokinetics (PK) and pharmacodynamics (PD) of CBZ, albeit the results were inconsistent. | Carbamazepine | epoxide hydrolase 1 | Homo sapiens |
| 4 | A significant correlation was detected between EPHX1 rs1051740 T > C polymorphisms and decreased plasma concentration of CBZ (TT vs CC: SMD = 0.34, P < 0.001; TC vs CC: SMD = 0.35, P = 0.009). | Carbamazepine | epoxide hydrolase 1 | Homo sapiens |
| 5 | CONCLUSION: EPHX1 rs1051740 T > C and rs2234922 A > G are important genetic variants associated with plasma CBZ concentration. | Carbamazepine | epoxide hydrolase 1 | Homo sapiens |
| 6 | The role of EPHX1 polymorphisms in the interindividual variability of plasma CBZ concentration varied significantly among different ethnic groups, which should be considered during clinical validation and in future studies. | Carbamazepine | epoxide hydrolase 1 | Homo sapiens |