Title : Design and Synthesis of Novel Ibuprofen Derivatives as Selective COX-2 Inhibitors and Potential Anti-Inflammatory Agents: Evaluation of PGE2, TNF-α, IL-6 and Histopathological Study.

Pub. Date : 2022

PMID : 34370644






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Design and Synthesis of Novel Ibuprofen Derivatives as Selective COX-2 inhibitors and potential anti-inflammatory agents: Evaluation of PGE2, TNF-alpha, IL-6 and histopathological study. Ibuprofen mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 BACKGROUND: The reported binding mode of ibuprofen in the COX-2 binding site indicated that the carboxylic group binds with Arg-120 and Tyr-355 at the entrance of the cyclooxygenase channel and does not extend into the pocket. Ibuprofen mitochondrially encoded cytochrome c oxidase II Homo sapiens