Pub. Date : 2022 Jan
PMID : 34370147
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The purpose of the study was to investigate the combined treatment of gastric tumorigenesis using Rapamycin and Fluorouracil (5-Fu) through interfering with the Akt/mTOR pathway in a mouse model with PTEN conditional deletion. | Sirolimus | mechanistic target of rapamycin kinase | Mus musculus |
| 2 | The combined Rapamycin administration with 5-Fu resulted in better outcomes than their separate administration for the treatment of gastric cancer by inhibiting the mTOR signal pathway. | Sirolimus | mechanistic target of rapamycin kinase | Mus musculus |
| 3 | Our study indicates that Rapamycin has a synergistic interaction with chemotherapeutic 5-Fu, and demonstrates a potential therapeutic combination treatment on glandular stomach tumor with PTEN functional absence or aberrantly activated Akt/mTOR pathway. | Sirolimus | mechanistic target of rapamycin kinase | Mus musculus |