Title : Combining SARS-CoV-2 Proofreading Exonuclease and RNA-Dependent RNA Polymerase Inhibitors as a Strategy to Combat COVID-19: A High-Throughput in silico Screening.

Pub. Date : 2021

PMID : 34354677






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Nucleoside analogs are the most promising RdRp inhibitors and have shown effectiveness in vitro, as well as in clinical settings. Nucleosides ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2
2 One limitation of such RdRp inhibitors is the removal of incorporated nucleoside analogs by SARS-CoV-2 exonuclease (ExoN). Nucleosides ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2