Pub. Date : 2021 Sep
PMID : 34332978
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Transient Receptor Potential vanilloid 1 (TRPV1) ion channel serves as the detector for noxious temperature above 42 C, pungent chemicals like capsaicin and acidic extracellular pH. | Capsaicin | transient receptor potential cation channel subfamily V member 1 | Homo sapiens |
| 2 | Transient Receptor Potential vanilloid 1 (TRPV1) ion channel serves as the detector for noxious temperature above 42 C, pungent chemicals like capsaicin and acidic extracellular pH. | Capsaicin | transient receptor potential cation channel subfamily V member 1 | Homo sapiens |
| 3 | We found that these endocannabinoid ligands bind to the vanilloid binding pocket of TRPV1 in the "tail-up, head-down" configuration, similar to capsaicin; however, there is a unique interaction with TRPV1 Y512 residue critical for endocannabinoid activation of TRPV1 channels. | Capsaicin | transient receptor potential cation channel subfamily V member 1 | Homo sapiens |
| 4 | We found that these endocannabinoid ligands bind to the vanilloid binding pocket of TRPV1 in the "tail-up, head-down" configuration, similar to capsaicin; however, there is a unique interaction with TRPV1 Y512 residue critical for endocannabinoid activation of TRPV1 channels. | Capsaicin | transient receptor potential cation channel subfamily V member 1 | Homo sapiens |
| 5 | These data suggest a differential structural mechanism is involved in TRPV1 activation by endocannabinoids compared to the classic agonist capsaicin. | Capsaicin | transient receptor potential cation channel subfamily V member 1 | Homo sapiens |