Title : Activation of κ-opioid receptor inhibits inflammatory response induced by sodium palmitate in human umbilical vein endothelial cells.

Pub. Date : 2021 Oct

PMID : 34332276






2 Functional Relationships(s)
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1 RESULTS: The SP-induced hyperlipidemic cell model demonstrated increased expression of NLRP3 and caspase-1 proteins (P < 0.05) and elevated ROS levels (P < 0.01), and decreased phosphorylated-Akt and phosphorylated-eNOS expression (P < 0.05). Palmitic Acid nitric oxide synthase 3 Homo sapiens
2 CONCLUSION: Our findings suggest that kappa-OR activation inhibits SP-induced inflammation by activating the PI3K/Akt/eNOS signaling pathway. Palmitic Acid nitric oxide synthase 3 Homo sapiens