Title : Infigratinib Is a Reversible Inhibitor and Mechanism-Based Inactivator of Cytochrome P450 3A4.

Pub. Date : 2021 Sep

PMID : 34326139






2 Functional Relationships(s)
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1 Co-incubation with testosterone (alternative CYP3A substrate) or ketoconazole (direct CYP3A inhibitor) attenuated the rate of inactivation whereas the inclusion of glutathione and catalase did not confer such protection. Testosterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Co-incubation with testosterone (alternative CYP3A substrate) or ketoconazole (direct CYP3A inhibitor) attenuated the rate of inactivation whereas the inclusion of glutathione and catalase did not confer such protection. Testosterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens