Title : PRMT4 inhibitor TP-064 inhibits the pro-inflammatory macrophage lipopolysaccharide response in vitro and ex vivo and induces peritonitis-associated neutrophilia in vivo.

Pub. Date : 2021 Nov 1

PMID : 34311083






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1 Similarly, thioglycollate-elicited peritoneal cells isolated from wildtype mice treated with TP-064 showed lowered mRNA expression levels and cytokine production of pro-inflammatory mediators interleukin (IL)-1beta, IL-6, IL-12p40, and tumor necrosis factor-alpha in response to lipopolysaccharide exposure. Thioglycolates tumor necrosis factor Mus musculus