Title : Selective Inhibition of the C-Domain of ACE (Angiotensin-Converting Enzyme) Combined With Inhibition of NEP (Neprilysin): A Potential New Therapy for Hypertension.

Pub. Date : 2021 Sep

PMID : 34304582






1 Functional Relationships(s)
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1 Omapatrilat, a dual NEP inhibitor-ACE inhibitor, was a promising antihypertensive drug but failed in trials due to angioedema, an effect possibly caused by inhibition of both the N- and C-domains of ACE. omapatrilat membrane metallo endopeptidase Mus musculus