Pub. Date : 2021 Aug
PMID : 34303883
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In MCF7 cells, letrozole caused a dose dependent increase in FADS2-catalyzed DGLA synthesis, which plateaued in SK-N-SH cells. | 8,11,14-Eicosatrienoic Acid | fatty acid desaturase 2 | Homo sapiens |
| 2 | CONCLUSION: Letrozole restores Delta6-desaturase mediated synthesis of the anti-inflammatory PGE1-precursor DGLA in vitro and is the first endocrine-active agent to have opposing effects on FADS1 and FADS2 catalyzed activities. | 8,11,14-Eicosatrienoic Acid | fatty acid desaturase 2 | Homo sapiens |