Pub. Date : 2021 Aug
PMID : 34303201
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Urine levels of the polyglutamine ataxin-3 protein are elevated in patients with spinocerebellar ataxia type 3. | polyglutamine | ataxin 3 | Homo sapiens |
| 2 | Urine levels of the polyglutamine ataxin-3 protein are elevated in patients with spinocerebellar ataxia type 3. | polyglutamine | ataxin 3 | Homo sapiens |
| 3 | INTRODUCTION: Accumulation of polyglutamine (polyQ) ataxin-3 (ATXN3) contributes to the pathobiology of spinocerebellar ataxia type 3 (SCA3). | polyglutamine | ataxin 3 | Homo sapiens |
| 4 | INTRODUCTION: Accumulation of polyglutamine (polyQ) ataxin-3 (ATXN3) contributes to the pathobiology of spinocerebellar ataxia type 3 (SCA3). | polyglutamine | ataxin 3 | Homo sapiens |
| 5 | INTRODUCTION: Accumulation of polyglutamine (polyQ) ataxin-3 (ATXN3) contributes to the pathobiology of spinocerebellar ataxia type 3 (SCA3). | polyglutamine | ataxin 3 | Homo sapiens |
| 6 | INTRODUCTION: Accumulation of polyglutamine (polyQ) ataxin-3 (ATXN3) contributes to the pathobiology of spinocerebellar ataxia type 3 (SCA3). | polyglutamine | ataxin 3 | Homo sapiens |
| 7 | INTRODUCTION: Accumulation of polyglutamine (polyQ) ataxin-3 (ATXN3) contributes to the pathobiology of spinocerebellar ataxia type 3 (SCA3). | polyglutamine | ataxin 3 | Homo sapiens |
| 8 | INTRODUCTION: Accumulation of polyglutamine (polyQ) ataxin-3 (ATXN3) contributes to the pathobiology of spinocerebellar ataxia type 3 (SCA3). | polyglutamine | ataxin 3 | Homo sapiens |
| 9 | Recently, we showed that polyQ ATXN3 is elevated in the plasma and cerebrospinal fluid (CSF) of SCA3 patients, and has the potential to serve as a biological marker for this disease (1). | polyglutamine | ataxin 3 | Homo sapiens |
| 10 | Based on these findings, we investigated whether polyQ ATXN3 can also be detected in urine samples from SCA3 patients. | polyglutamine | ataxin 3 | Homo sapiens |
| 11 | RESULTS: PolyQ ATXN3 can be detected in the urine of SCA3 patients, but not in urine samples from healthy controls or other forms of ataxia. | polyglutamine | ataxin 3 | Homo sapiens |
| 12 | There was a significant statistical association between polyQ ATXN3 levels in urine samples and those in plasma. | polyglutamine | ataxin 3 | Homo sapiens |
| 13 | Further, the levels of polyQ ATXN3 urine associated with an earlier age of SCA3 disease onset. | polyglutamine | ataxin 3 | Homo sapiens |